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September 20, 2019
The pharmacokinetics of injectable weight loss medications remain largely unchanged after gallbladder removal
STEP and SELECT Trial Data, What Researchers Are Working From The pivotal STEP 1 trial (Wilding et al., NEJM 2021, NCT03548935) enrolled 1,961 adults with obesity (no T2D) over 68 weeks at the 2.4mg/week dose
But not everyone responded equally
By shrinking visceral fat stores, GLP-1s help decrease the release of inflammatory cytokines, which contributes to improved blood sugar control, lower blood pressure, and a healthier lipid profile
For example, lapatinib induces ferroptosis via iron-dependent ROS generation in the early stages but promotes protective autophagy to facilitate drug resistance in the later stages [157]
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