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PLoS ONE 7 , e40156 (2012)
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Liu, Zinc enhances chemosensitivity to Paclitaxel in PC3 prostate cancer cells
Environmental factors like UV exposure or pollution accelerate this by inducing more DNA damage, thus more PARP activity
Methods: Authors used a computer-based gene profiling tool, The Connectivity Map, to identify a number of human genes regulated by GHK, relevant to regulation of cell differentiation, apoptosis and stem cell function
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