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doi: 10.1089/thy.2014.0460 46 MathewsJDForsytheAVBradyZButlerMWGoergenSKByrnesGBet al

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In addition, they may have other modes of action, as causing oxidative stress, genetic susceptibility, and epigenetic modifications (e.g., DNA methylation, miRNA) (17, 62, 63), ultimately resulting in gene expression changes (62, 64, 65) in particular when exposure occurs during prenatal and early postnatal life

Utilizing a sophisticated multi-pathway delivery system, this formulation works by concurrently modulating the organized activation of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG) receptors

Second, as AID is the most advanced insulin therapy, the placebo arm represented the best commercially available treatment for T1D at this time