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Although clinically, modern-day antibiotics have been shown to be more effective in treating acne than zinc, several studies show zincs effectiveness to be about on a par with antibiotics of the 70s and 80s

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[2] [254] The known metabolic pathways, detectable metabolites, and metabolizing enzymes in humans include the following: Pharmacomicrobiomics The human metagenome (i.e., the genetic composition of an individual and all microorganisms that reside on or within the individual's body) varies considerably between individuals

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This is a compound that is sort of like a hormetic compound, or as David Sinclair likes to say, it's a xenohormetic compound