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To meet surging demand, many companies rely on compounded semaglutide - unapproved versions of the active ingredient in Ozempic and Wegovy - produced by third-party pharmacies

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Both compounds engage the anterior pituitary somatotroph cells where growth hormone is synthesised and released, but they bind different receptors and operate through different intracellular pathways the rationale for combined-compound research that motivates this blend format

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Scalise et al., 2018)