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Several groups have demonstrated that continuous systemic administration of rotenone to rats and mice reproduces key features of PD, including selective degeneration of the nigrostriatal dopaminergic system, activation of astroglia and microglia, formation of cytoplasmic inclusions in neurons, movement disorders, and defects in mitochondrial complex I [11, 14, 57, 62-64]

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Some people notice better wellbeing after the very first infusion, but the effects described in studies were temporary and faded within a few months of finishing the series

doi: 10.1186/s13293-021-00367-2 15 DelitalaAPScuteriADoriaC