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Cushman CJ et al
In the initial larger, higher resolution, dataset of Cagri-CTR-Gs ( N = 1), density was observed for the proximal region of the conjugated lipid at the peptide N-terminus that was consistent regardless of peptide conformation (bypass or CT-like) and supports modelling the Glu linker and a short segment of acyl chain in a different orientation to that observed in the AMY 1 R complex (Figs
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Dopamine, which acts as a neurotransmitter in the CNS is well known to not cross the BBB [68] due to lack of specific transporter and active metabolism in brain endothelial cells
Hyperglycemia may directly cause oxidative stress in all retinal cells or contribute to oxygen deficits in the inner retinal layers due to the retinas high metabolic activity, making it prone to oxidative stress
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