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Only a few examples of fluorescent probes have been reported to selectively detect GSH 28,29,30,31,32 and even fewer for the detection in the cellular environment 33,34,35,36,37

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The tradeoff is convenience measuring powder is less portable than taking a capsule, and some people may find NAC's sulfur-like taste unpleasant

Hence, ensuring that RNAi constructs can get through the blood-brain barrier without breaking down and can accurately hit their target in the brain is of prime importance for the PD patients

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