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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)
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Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review
Nebert DW, Vasiliou V
It is estimated that PD affects at least 1% of the population over the age of 60 (Zafar and Yaddanapudi, 2023)
A reduction in left atrial dilation, ventricular hypertrophy, and higher atrial fibrillation was observed
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