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Currently approved treatments such as tetrabenazine and deutetrabenazine target only chorea and offer symptomatic relief without altering disease progression

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Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P

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Importantly, elevated KYNA in the CNS may contribute to cognitive deficits in schizophrenia by antagonizing 7nAChRs and NMDARs, which are critical for synaptic plasticity, working memory, and cortical network coordination [76, 240,241,242]

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