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GLP-1R is expressed in several brain regions, including the hippocampus and cortex, where it may influence synaptic plasticity, neuroinflammation, and cellular energy metabolism [88,89]

Tran S, Retnakaran R, Zinman B, Kramer CK (2018) Efficacy of glucagon-like peptide-1 receptor agonists compared to dipeptidyl peptidase-4 inhibitors for the management of type 2 diabetes: a meta-analysis of randomized clinical trials

This process, combined with the effects of GLP-1 Peptides, makes weight loss easier

This data suggests that while lower doses (5-15g) are excellent for maintenance and mild IBS, repairing severe, pathological "leaky gut" may require transient, high-dose interventions under medical supervision to rapidly force the reassembly of tight junction proteins

Less effective than Semaglutide for most patients

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