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This reaction has two consequences studied in the literature: it consumes S-adenosyl methionine, the cells principal methyl donor, and it removes nicotinamide from the salvage pathway that regenerates NAD+

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In 2014, the US Food and Drug Administration (FDA) acknowledged a GRAS (Generally Recognised as Safe) notification for AOD 9604 as a food ingredient meaning the FDA raised no questions about the notifier's own safety conclusion

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