Safety Considerations and Contraindications GLP-1 medications have important safety considerations regardless of whether they are FDA-approved or compounded formulations
GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)are used to manage type 2 diabetes and obesity in the UK
Benefit 6: Reduces Chronic Inflammation Chronic inflammation underlies many illnesses, including autoimmune diseases, vector-borne illnesses like Lyme disease and co-infections, IBD, and lung conditions like asthma, COPD, cystic fibrosis
7.2 mg weekly (Wegovy HD) for adults who tolerated 2.4 mg for at least 4 weeks and need more weight loss
Factor #2: PCOS improvement happens faster than expected For women with PCOS, GLP-1s create a perfect storm of fertility improvement through improved insulin sensitivity (which is often the root problem in PCOS), reduced androgen levels as testosterone and other androgens drop when insulin improves, ongoing weight loss effects where each pound lost further improves hormonal balance, and potentially direct ovarian effects as some evidence suggests GLP-1s may directly improve ovarian function
Journal of Hepatology, Volume 81, Issue 3, 492-542