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In vitro , BL increases the expression of GPX4, FTH1, mitochondrial ferritin (FTMT), and SLC7A11 (a key subunit of system Xc-), and ACSL3, while decreasing the expression of ACSL4 and total iron levels in OGD/R-treated HT22 cells, with effects being dose-dependent (Li M
Caiafa, P., Guastafierro, T
Research Background IGF-1 LR3 has been studied in research on cellular proliferation, muscle and tendon biology, and somatotropic axis pharmacology
Disruption of this axis, by either pharmacological inhibition or genetic ablation, leads to ferroptotic cell death
Rochester: SSRN (2025)
Preclinical study of the metabolic pathway disruptions that give rise to these biomarkers facilitates enhanced understanding of TBI pathology and identification of new therapeutic targets
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