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The combination may theoretically offer complementary benefits, as both compounds address insulin resistance through distinct pathways
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Analysis of calcium ion (Ca 2+ ) levels in macrophages To detect the intracellular Ca 2+ content, 143B cells were incubated with PBS, Ru(II)-OH, NP2, and NP4 (Ru 10 M) for 6 h
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In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination
