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In animal models of PCOS, organic zinc supplementation has been associated with downregulation of the mammalian target of rapamycin (mTOR) gene regarding expression which is a critical modulator of cell growth and metabolism
Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)
This condition can result from chronic pancreatitis, cystic fibrosis, pancreatic cancer, or other pancreatic disorders
CMAJ 192 , E875E891 (2020)
