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sustained GH elevation through chronic use of any secretagogue could push glucose handling in the wrong direction, particularly in people with pre-existing insulin resistance

To conclude, in this report we have provided the first, to our knowledge, comprehensive biochemical analysis of a TGR selenoprotein from any organism , showing that it has remarkably wide substrate specificity and may be effectively inhibited by a number of low-molecular-weight compounds

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PMID: 29683489

For further coverage of this issue see the following references (6, 30, 35, 99, 100)