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doi: 10.1080/10590500903310047 22 CohnBALa MerrillMKrigbaumNYYehGParkJ-SZimmermannLet al

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By raising intragastric pH, Deu 20 mg can significantly alter the absorption of drugs whose solubility depends on gastric acidity: Because Deu 20 mg is metabolized by and can inhibit CYP2C19, co-administration may delay the elimination of the following drugs, potentially increasing their plasma levels and risk of adverse effects: Concomitant administration of Deu 20 mg and Clarithromycin results in mutually increased plasma concentrations of both drugs

(Its Not New) Berberine is a bioactive compound found in several plants, including goldenseal, barberry, and Oregon grape