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7 Recent advances and clinical trials for neurodegenerative diseases 7.1 NP-based siRNA delivery for ADs The instability of siRNA therapy in the circulation and the fact that it is unable to reach target cells in the central nervous system (91, 92) because of the BBB poses the biggest hurdle in siRNA therapy
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Physiol Rev 95:513548 Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ (2014) Neuronal GLP1R mediates liraglutides anorectic but not glucose-lowering effect
The consequence that actually shows up on a bench is this: in a serum-containing medium, the free fraction of added IGF-1 LR3 is much higher than the free fraction of an equal mass of native IGF-1, and it is far less buffered, because the binding-protein reservoir that would normally absorb an excess and release it slowly is largely not engaging with this molecule
It applies to semaglutide and tirzepatide users equally
Most patients wont notice a change right away
