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All analyses were performed using GraphPad Prism version 9.0

12 ] In humans, melatonin production often declines with age, which may contribute to sleep disturbances and disruptions in normal biological timing

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Endoscopic ultrasound after preoperative chemoradiation can help identify patients who benefit maximally after surgical esophageal resection

This action accelerates wound closure and reinforces barrier function by up-regulating collagen synthesis genes and down-regulating pro-inflammatory cytokines like TNF-