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A practical starting point is targeting a 510% reduction in your initial body weight
However, outcomes depend heavily on dosage, treatment frequency, and patient metabolism
Over the last couple of decades, Pratley says, the scientific research community has learned that incretin hormones, including GLP-1, GIP, and others, are important regulators of metabolism with impacts on glycemia, lipids, and body weight
Weight loss and improved insulin sensitivity also play important roles
The analysis found only a modest decrease in stroke risk (13% lower relative risk reduction) and a nonsignificant trend (14% lower relative risk reduction) for heart attack risk
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However, some patients report cramping, likely due to indirect factors such as electrolyte disturbances or rapid weight loss rather than direct drug effects
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