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In addition to improving insulin resistance, a hypothesized mechanism in the progression of PD, in vitro and in vivo studies have shown that GLP-1 RAs can inhibit many pathways present in the pathogenesis of PD

Blood 107(12):47704780 Pu H, Hayashi K, Andras IE, Eum S, Hennig B, Toborek M (2007) Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the bloodbrain barrier

Or worse, they experience side effects that could have been avoided entirely

doi:10.3390/jcm10091891

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In melanocytes, these transcription factors bind to the promoter of MITF-M to regulate MITF expression whilst controlling the transcription of several important genes