Early research on Retatrutide showed participants losing up to 24% of their body weight over 48 weeks at the highest dose
Poor sleep increases hunger (via higher ghrelin and lower leptin), raises cortisol levels that promote fat storage, and reduces willpower and recovery, making it harder to stick to healthy habits
Potential Side Effects of Anti-Obesity Drugs While anti-obesity drugs offer a promising approach to weight management, they can also cause side effects
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In 2023, the American Society for Reproductive Medicine said that GLP-1 medications like Ozempic can be considered for adults with PCOS who are of higher weight, along with healthy lifestyle changes
While more research is needed, the data hint at a potential protective effect on joint tissues themselves