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14 Little is known about the capacity of exogenously administered GSH, or its precursors, to modify CNS GSH levels

151 While preclinical/clinical studies suggest that the dual/pan-PPAR agonists have a more significant effect in the treatment of disease when compared with PPAR or PPAR agonists alone, improvement of the low agonistic activity and low metabolic stability of multiple agonists may still need to be improved

In preclinical models, this nanoplatform effectively reduces MDSC populations, reactivates antitumor immunity, and inhibits tumor growth with a favorable safety profile (31)

Anderberg RH, et al

Diabetes Metab 2024;50:101506

Fat is the primary target