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So, I decided to try both
10.1186/s11658-021-00271-y 63 GalluzziL.VitaleI.AaronsonS
D.Dykes-HobergM.CorsonL
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In T eff cells, the metabolic state is changed to increasingly rely on glycolysis, as these cells upregulate GLUT1, increase glucose intake
Thus, CHAC1 serves a dual role: it preserves mitochondrial function by ensuring a cysteine supply under nutrient stress, but it also facilitates ferroptosis by maintaining ETC activity, highlighting its potential as a therapeutic target in cancer treatment (Ward et al., 2024)
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