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Food and Chemical Toxicology, 62 , 869875
The etiology remains unknown, and there is currently no curative treatment
PLoS ONE 4:e5301
Due to its ability to bind to ER receptors in the uterus and form a complex that interacts with DNA in the nucleus to activate transcriptional promoter and enhancer regions that govern gene expression, estradiol is unique in its ability to promote the growth of uterine cells
The oxidative effects of these transition metals can promote the formation of hydrogen peroxide and also enhance subsequent iron- and copper-induced lipid peroxidation (Miller et al., 1991
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