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Further work is required to elucidate the relationship between GLP-1 RAs and neurohormonal activation, including the RAAS, and whether there are any implications for renal or systemic hemodynamic function, or clinical endpoints

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Critical adjustment period Early months require guidance for dosing, tolerance, & progress for long-term success 2x Longer on therapy Ongoing support keeps patients on GLP-1s 2x longer, maximizing long-term benefits 9+ Systems affected GLP-1s influence brain, heart, kidney, & more

Foy and Furman, 1969

Hence, low levels of serotonin, a substance essential in elevating mood, may be produced in people with vitamin B12 insufficiency

Obesity and type 2 diabetes: what can be unified and what needs to be individualized