Because tyrosine differs from phenylalanine by a single hydroxyl group, AOD9604 and the unmodified 176-191 sequence are both 16-residue peptides that differ by exactly one oxygen atom 1,815.1 g/mol versus 1,799.1 g/mol
help regulate appetite and mood (key factors in overeating)
10.1007/s11064-004-9691-6 20
Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)
Animal trials suggest perks such as diminished testicular harm and inflammation
Many people have reduced absorption due to age, medication, or digestive issues