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Below is a clinical framework of gastrointestinal effects reported across GLP-1 clinical trials and real-world use
Ellenbroek et al (32) reported pancreatic weight was increased after 6 weeks on liraglutide with a 65% increase in proliferating acinar cells and no change in duct cell proliferation
Patients with chronic kidney disease, heart failure, or a history of medullary thyroid cancer require additional screening before GLP-1 therapy
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