small molecule glp 1 agonist In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with Small-molecule agonists activate the Ga

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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)

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PMID: 39747971 Brain Res Bull Nerol ameliorates cognitive dysfunction in vascular dementia rats by inhibiting mitochondrial oxidative stress and reducing hippocampal senescence