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Activation of MC1R via Gs cAMP MITF (the master transcription factor of melanogenesis) leads to: Activation of tyrosinase , the key enzyme of melanin synthesis Conversion of pheomelanin (red/yellow pigment) to eumelanin (black/brown)
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Reducing CHAC1 expression in these cells improves cell viability, lowers ROS levels, and restores mitochondrial integrity, indicating CHAC1s essential role in ferroptotic cell death
The latter is usually split into one or two doses
