This maintains effectiveness while reducing potential for excess accumulation
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The cochlea operates as a nearly closed system, limiting its ability to eliminate toxins at the rate of their accumulation
Although Neto2 binding to the receptor does not appear to alter the behavior of individual or dimeric ATDs, LBDs, or the ion channel pore, the presence of Neto2 inhibited tightening of the interface between the two LBD dimers during activation and consequently decelerated the kinetics of receptor deactivation (Gangwar et al., 2025)
Lycopene is one of the most powerful antioxidants among carotenoids, as it activates the WNT/-catenin and ERK1/2 pathways, upregulating RUNX2, ALP, and type I collagen, while downregulating RANKL
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