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High doses are given to increase intestinal concentration, allowing enough B12 absorption to meet the body's needs

Free histidine and lysine (both components of GHK) increase in circulation, creating theoretical competition for copper at the injection site as the peptide diffuses into capillary beds

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Phase 2 trial (Lancet 2021) tested cagrilintide 0.3 mg through 4.5 mg/week as monotherapy and reported a clear dose-response, with 10.8% mean weight loss at 4.5 mg/week at 26 weeks

Energy Storage 60 , 106713 (2023)

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