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The SURMOUNT-4 trial demonstrated that participants who discontinued tirzepatide after achieving weight loss regained a substantial portion of their lost weight over the subsequent 52 weeks, while those who continued treatment maintained their weight reduction

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Identification of upregulated or downregulated serum markers such as nucleic acids, proteins, exosomes, lipids, and circulating tumor cells may unravel novel or key metastatic pathways that can be further dissected, and therapies developed against them