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GLP-1 is a target for treatment of diabetes because of the primary peripheral functions of inducing insulin secretion from pancreatic cells, gut emptying and inhibiting glucagon secretion which results in lower blood glucose levels (20)
The likelihood ratio based on the objective function value was used to test different hypotheses regarding the structure of the variancecovariance matrix for inter-individual variability and residual variability models, and to assess the covariate effects on toxicokinetic parameters
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The signature of class B GPCRs is a ~15 kDa N-terminal extracellular domain (ECD) essential for binding to the C-terminal part of the cognate peptide hormones
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