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However, some individuals experience persistent changes in sleep architecture, including lighter REM sleep or earlier wake times, which warrant discussion with your healthcare provider to distinguish adaptation from adverse effects

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doi: 10.3390/nu15061496 104 MargolisK

performed under local/tumescent anesthesia with micro-cannulas

Participants who had already lost weight through diet and exercise continued losing additional weight with tirzepatide, demonstrating that the drug adds meaningful benefit even when combined with non-pharmacological approaches