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Start your intake What Clinical Evidence Shows About GLP-1 and Long-Term Use Major clinical trials, including SUSTAIN-6 for semaglutide and SURMOUNT studies for tirzepatide, followed patients for 68 weeks to over two years

The following features, in isolation or combination, should prompt consideration of a possible seizure disorder and discussion with a clinician: Sudden, brief episodes of unresponsiveness or vacant staring that have a very abrupt onset and offset , particularly if they occur repeatedly and are associated with interruption of ongoing activity, may represent absence seizures. Unusual episodic sensory experiences, including odd smells, visual disturbances, a rising sensation in the abdomen or a sudden sense of fear without obvious cause, may represent focal seizure activity. Repetitive purposeless movements such as lip smacking, hand fumbling, chewing or swallowing occurring during episodes of altered awareness are associated with temporal lobe seizures

Kushner emphasize the need for ongoing research into weight control and its impact on preventing chronic illnesses

If you experience anaphylaxis or angioedema, the medication should be permanently discontinued and not restarted

In December 2023, the European Medicines Agencys Pharmacovigilance Risk Assessment Committee announced an update on its review of GLP-1 RAs and suicidal thoughts and thoughts of self-harm, which began in July 2023

Rising Concern About Semaglutide and Eye Safety Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has become a cornerstone therapy for type 2 diabetes and weight management, with millions of patients benefiting from improved glycaemic control and cardiovascular outcomes