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Furthermore, alanine mutations of the established glutathione-scaffold site residue D90 or of crucial residue K26 in monothiol PfGrx C32S/C88S slowed down the reaction and resulted in linear secondary diagrams for the first rate constant (Fig

Pharmacological GLP-1RA Action Key Mechanistic Distinctions A comprehensive review published in Cell Metabolism reviewed circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1R-positive cell types and pathways transducing metabolic and non-glycaemic GLP-1 signals

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We are in the very early history of these medications, and large-scale studies on efficacy and side-effects are lacking

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