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Compared to age-matched controls, insulin resistance in the brains of PD patients is independent of peripheral insulin resistance and manifests as severe abnormalities in brain insulin signal transduction

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Semaglutide, which belongs to a category of drugs known as GLP-1 or glucagon-like peptide-1, has also been used off-label for weight loss

However, if moderate-to-severe nausea or vomiting was reported for three or more days in the week before the next scheduled study visit, the dose was maintained or decreased at the investigators discretion [Citation22]