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For patients with type 2 diabetes, the American Diabetes Association (ADA) Standards of Care emphasize individualized glycemic targets and treatment selection based on patient-specific factors including baseline hemoglobin A1c (HbA1c), presence of atherosclerotic cardiovascular disease (ASCVD), heart failure, or chronic kidney disease, hypoglycemia risk, weight considerations, and patient preferences

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NICE guideline NG28 recommends individualised HbA1c targets: typically 48 mmol/mol (6.5%) for adults with type 2 diabetes managed by diet and drugs that don't cause hypoglycaemia, and 53 mmol/mol (7.0%) for those on medicines that can cause hypoglycaemia (such as sulfonylureas or insulin)

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