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[57] Semaglutide acts on these alterations by mitigating adipocyte hypertrophy and limiting excessive lipid storage through the downregulation of lipogenic enzymes such as lipoprotein lipase (LPL) and ANGPTL4
[3] For patients experiencing significant weight loss, many clinicians suggest protein intake of approximately 1.2 to 1.6 grams per kilogram of body weight daily to minimize lean tissue loss, though requirements should be individualized with healthcare provider guidance
Physiol Rev (2011) 91:102370
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The diagnosis is usually delayed until neurological complications arise from massive extension into surrounding structures, leading to cranial nerve palsies, hydrocephalus, temporal epilepsy or exophthalmos
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