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Melanotan I (afamelanotide) is more MC1R-selective and focused on pigmentation, while Melanotan II is non-selective across MC1R, MC3R, MC4R and MC5R, giving it a broader research effect profile including sexual-function pathways

The corresponding estimates among non-responders were 3.7% and 4%, respectively

Yoshida et al., 2021

October 24, 2024

When we stop supplementation, the natural state of melanin production may slowly come back

The ASA's guidance is clear: phrases like "decrease appetite", "burn fat", and "speed up metabolism" generally fall under medicinal claims, and supplement products aren't allowed to make them without authorisation