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"The gaunt appearance patients experience is due not only to volume loss, but it may also cause changes in the facial skin, including a reduction in collagen, elastin and essential nutrients

29,37 The biological basis of these differences remains poorly understood, and current evidence is largely derived from adult populations

Barreiro, E., Gea, J., Corominas, J

Mitophagy is a specific form of autophagy that eliminate damaged mitochondria in cells (Frank et al

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The studies in mammals and rainbow trout reported that leucine can effectively stimulate mTOR signalling 54,55