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The sustained effects of a dual GIP/GLP-1 receptor agonist, NNC00902746, in patients with type 2 diabetes

Add a side of baby carrots for 2 more grams, making this a 12-gram fiber meal

Mounjaro is a combination of GLP-1 and GIP receptor agonists, whereas Wegovy, a higher-dose formulation of Ozempic, works primarily through GLP-1 receptor agonism

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These drugs mediate the release of DAMPs following hepatocyte injury, which are sensed by, for example, Kupffer cells (KCs), activating innate immune receptors to trigger intracellular events leading to the release of pro-inflammatory mediators, cytokines, and chemokines, and then recruit neutrophils and monocytes to the blood in a sterile inflammatory process

Epub 2016 Dec 19