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Whilst highly effective, these medications can cause gastrointestinal side effects including nausea, vomiting, and diarrhoea, potentially leading to fluid and electrolyte losses
(3) Drug Delivery Innovation: a
The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite
Following the intake of nutrients, the beginning of the incretin effect is marked by rising levels of active GLP-1 which promote the synthesis and release of insulin 1,2,4
10.3389/fendo.2020.00025 21
o , Application of GLP-1 and GLP-1MK-801 induced changes in fluorescence indicative of rises in intracellular calcium (%F/F 0 ) as shown by these representative fluorescent responses of two different Fura 2-AM loaded cells to application of GLP-1 (1 M) or GLP-1MK-801 (1 M)
