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Immunopharmacology 97, 107667

Il stabilise les membranes cellulaires et limite les dommages causs par le stress oxydatif li la pollution, au tabac ou linflammation

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These findings provide evidence for the importance of the GSH system in anti-ferroptosis

Notably, breast cancer cells achieve metabolic adaptation by hijacking the autophagy mechanism: under glucose-deprivation conditions, MANF-mediated mitophagy eliminates dysfunctional mitochondria through the PRKN/Parkin-dependent pathway, maintains the ATP supply and promotes tumour survival [112], suggesting that targeting the MANFPRKN interaction can break the drug resistance barrier of breast cancer under metabolic stress