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2.1.3.4 Altered macrophage polarization (M1/M2 balance) Macrophages are plastic and can shift phenotypes depending on cues classically activated M1 are pro-inflammatory and microbicidal, whereas alternatively activated M2 are anti-inflammatory and involved in repair ( Figure 2 )

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Combination formulations that include GLP-1 medications with other weight management or diabetes medications in a single delivery system are also being explored