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doi: 10.1377/hlthaff.2024.01006
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Telomerase Activator Supporting cellular longevity at the telomere level
BRCA1, which regulates cell cycle progression, DNA damage signalling and repair, and maintenance of genomic integrity, interacts with NRF2 either directly, through its ETGE motif, preventing KEAP1-dependent ubiquitination of NRF2 and protecting cells against OS, or indirectly, through the interaction with CBP or with c-Myc [186]
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Prof Douglas Higgs, also from Oxford University, pointed out that not all the patients had become free of transfusions and there was still little known about the long-term effects of manipulating the genome of stem cells in this way
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