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Notably, our lead compound KL1 reduced ROS/RNS production in macrophages, sensitized intracellular persisters to antibiotics, and enhanced antibiotic efficacy in murine infection models

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Rogers ME, Jani MK, Vogt RG

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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible