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The gradual titration schedule serves multiple clinical purposes
It is a big deal, because it is really solidifying the idea that obesity is a chronic and relapsing disease that does need chronic management
Feb 13, 2026 One full syringe
Metformin users, common among type 2 diabetes patients who then add semaglutide, face a double hit since metformin independently reduces B12 absorption by 10-30% over long-term use
Updated 1/2/2020
SELECT trial: 20% reduction in MACE (HR 0.80, 95% CI 0.72-0.90)
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